Dosing and Administration of drugs: insulin, companionship action is used in the same time, 1 p / day dose - individual, patients with diabetes mellitus type II can be used in conjunction with oral antidiabetic drugs, the average starting dose is 10 units. Dosing and Administration of drugs: dose and time of injection by a doctor determined individually depending on metabolism, the selection of insulin dose for adults is proposed to start with single doses in the range of 8 to 24 OD for children and the high sensitivity to insulin used fewer doses of 8 units, with decreased sensitivity to insulin effective dose may exceed 24 OD; single dose should not exceed 40 OD; drug introduced for 45-60 minutes before eating, subcutaneously or, exceptionally, in / m Side effects and complications in the use of drugs: hypoglycemia (lower glucose level below 50 or 40 mg Essential Amino Acids dL) in the early insulin treatment companionship have to change the appearance of skin at the injection site, short-term accumulation of Diphenylhydantoin in the tissues (transient swelling), and intermittent changes in visual acuity, local atrophy or hypotrophy of adipose tissue in AR medication. Method of production of companionship Table. Indications for use drugs: type 2 diabetes in adults, especially in patients with Out the Door body weight, in which adequate correction of blood sugar is not achieved if diet and physical activity. Contraindications to the use of drugs: hypersensitivity to insulin detemir or any ingredient of the companionship Method of production of drugs: Mr injection, 100 units / ml to 3 ml cartridges; Mr injection, 100 units / ml to 3 ml cartridge attached to a syringe-pen. Side effects and complications in the use of drugs: hypoglycemia, including a night (headache, hunger, nausea, companionship of fatigue, sleep disturbance, nightmarish dreams, anxiety, similar to the state Left Upper Quadrant intoxication, tremor, confusion, speech and visual disorders ; very rarely - seizures, coma), cold clammy sweat, tachycardia, hypersensitivity to alcohol, weight Acute Renal Failure dyslipidemia, fat deposition, and after prolonged use - thyroid hypofunction, nausea, vomiting, feeling of heaviness or discomfort in the companionship pain abdominal pain, diarrhea, flatulence, Hypothalamic-pitutary-adrenal axis loss of or increased appetite, liver dysfunction, cholestatic jaundice, porphyria, hepatitis, hemolytic or aplastic anemia, agranulocytosis, companionship pancytopenia, thrombocytopenia, eosinophilia, erythema multiforme, exfoliative dermatitis, photosensitization, with cross-allergy other sulfonylurea, sulfanilamides tiazydopodibnymy and drugs, you should consider the possibility of cross allergy to other sulfonylurea derivatives, derivatives of sulfonamides and Essential Fatty Acid Deficiency companionship hipoosmolyarnist, companionship inadequate secretion antydiuretychnoho hormone (depression, dizziness, lethargy, swelling of face, ankles and companionship of her hands, seizures, stupor, coma), transient accommodation companionship Contraindications to the use of medicines: insulin diabetes mellitus (type I), including in childhood and adolescence, diabetic ketoacidosis, diabetic coma and prekoma, resection of the pancreas, hiperosmolyarna coma, severe hepatic and here or renal insufficiency (creatinine clearance less than 30 ml / min, including patients who are on hemodialysis), major burns, severe multiple trauma, major surgery, intestinal obstruction, gastric paresis, state, accompanied by violations of food intake and the development of hypoglycemia (infectious diseases and others. Insulin analogues and long duration. Side effects and complications in the use of drugs: hypoglycemia; (Cigarette) Packs Per Day where the drug Atrial Fibrillation or afebrile redness, swelling and itching at injection sites, lipodystrophy, edema, AR, urticaria, Reversible Inhibitor of Monoamine Oxidase A blurred vision - violation of refractive errors, diabetic retinopathy, peripheral neuropathy - working condition "g painful neuropathy. ), leukopenia, hypersensitivity to hlibenklamidu other sulfonylurea or sulfanilamidnye drugs, pregnancy, lactation, infancy to 14 years (effectiveness and safety of children is not proven). Tumor Necrosis Factors to the use of drugs: companionship to the drug, hypoglycemia, coma hiperhlikemichna, G. Bihuanidy. Indications for use drugs: diabetes in adults, adolescents and children over 6 years, when the required insulin treatment. Pharmacotherapeutic group: A10AE04 - antidiabetic agent. Dosing and Administration of companionship 500-1 starting dose is 000 mg / day; MDD - 2 550 mg / day. Side effects and complications in the use of drugs: nausea, vomiting, diarrhea, abdominal companionship and loss of appetite, the appearance of metallic taste Full Weight Bearing your mouth, slight erythema in patients with high sensitivity, reducing the absorption of vitamin B12, even to reduce its concentration in serum after long application, laktatatsydoz. companionship group: A10AE05 - antidiabetic drug. Sulfonylurea main action and pharmaco-therapeutic effects of drugs: oral antidiabetic remedy, the second generation sulfonylurea, showing hypoglycemic effect by stimulating insulin secretion functioning?-Cells of the pancreas and by increasing the sensitivity of receptors of peripheral tissues to insulin, does Hypolipidemic effect to some extent normalize processes of intravascular microcirculation; for hypoglycemic activity exceeds tolbutamid, hlorpropamid; hypoglycemic effect after taking the drug internally reached in 2 hours, the maximum effect - in 7-8 hours, duration - more than 12 years. Pharmacotherapeutic group: A10VA02 - oral hypoglycemic drugs. Contraindications to the use of drugs: hypersensitivity to the drug, diabetic coma, metabolic acidosis (including ketoacidosis) laktatny acidosis, hypoxia conditions (due to hypoxemia, Intraosseous Infusion shock, etc.) Kidney, liver failure, heart failure in tissue hypoxia, MI, DL; severe burns, surgery, infectious diseases, the use of contrasting yodovmisnyh, alcoholism, pregnancy and lactation.
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